The scaffolding protein IQGAP1 interacts with Nucleotide Binding Domain Leucine Rich Repeat CARD containing protein (NLRC3) and inhibits type I interferon production

Sensing of cytosolic nucleotides is a critical initial step in the elaboration of type I interferon. One of several upstream receptor cGAS (cyclic-GMP-AMP synthase) binds to cytosolic DNA and generates di-cyclic nucleotides that act as secondary messengers. These secondary messengers bind directly t...

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Publicado no:J Immunol
Main Authors: Tocker, Aaron M., Durocher, Emily, Jacob, Kimberly D., Trieschman, Kate E., Talento, Suzanna M., Rechnitzer, Alma A., Roberts, David M., Davis, Beckley K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714304/
https://ncbi.nlm.nih.gov/pubmed/28864474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601370
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