Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency

INTRODUCTION: COPD has complex etiologies involving both genetic and environmental determinants. Among genetic determinants, the most recognized is a severe PiZZ (Glu342Lys) inherited alpha1-antitrypsin deficiency (AATD). Nonetheless, AATD patients present a heterogeneous clinical evolution, which h...

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Detalhes bibliográficos
Publicado no:Int J Chron Obstruct Pulmon Dis
Main Authors: Esquinas, Cristina, Janciauskiene, Sabina, Gonzalo, Ricardo, Mas de Xaxars, Gemma, Olejnicka, Beata, Belmonte, Irene, Barrecheguren, Miriam, Rodriguez, Esther, Nuñez, Alexa, Rodriguez-Frias, Francisco, Miravitlles, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713702/
https://ncbi.nlm.nih.gov/pubmed/29238183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S145445
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