Development of a Novel CD4(+) TCR Transgenic Line That Reveals a Dominant Role for CD8(+) Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria

We describe an MHC class II (I-A(b))–restricted TCR transgenic mouse line that produces CD4(+) T cells specific for Plasmodium species. This line, termed PbT-II, was derived from a CD4(+) T cell hybridoma generated to blood-stage Plasmodium berghei ANKA (PbA). PbT-II cells responded to all Plasmodiu...

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Publicado no:J Immunol
Main Authors: Fernandez-Ruiz, Daniel, Lau, Lei Shong, Ghazanfari, Nazanin, Jones, Claerwen M., Ng, Wei Yi, Davey, Gayle M., Berthold, Dorothee, Holz, Lauren, Kato, Yu, Enders, Matthias H., Bayarsaikhan, Ganchimeg, Hendriks, Sanne H., Lansink, Lianne I. M., Engel, Jessica A., Soon, Megan S. F., James, Kylie R., Cozijnsen, Anton, Mollard, Vanessa, Uboldi, Alessandro D., Tonkin, Christopher J., de Koning-Ward, Tania F., Gilson, Paul R., Kaisho, Tsuneyasu, Haque, Ashraful, Crabb, Brendan S., Carbone, Francis R., McFadden, Geoffrey I., Heath, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Novel Immunological Methods
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713497/
https://ncbi.nlm.nih.gov/pubmed/29084838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700186
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