Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

OBJECTIVE: Assuming that mesenchymal stem cells (MSCs) respond to the osteoarthritic joint environment to exert a chondroprotective effect, we aimed at investigating the molecular response setup by MSCs after priming by osteoarthritic chondrocytes in cocultures. METHODS: We used primary human osteoa...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Maumus, Marie, Manferdini, Cristina, Toupet, Karine, Chuchana, Paul, Casteilla, Louis, Gachet, Mélanie, Jorgensen, Christian, Lisignoli, Gina, Noël, Danièle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712679/
https://ncbi.nlm.nih.gov/pubmed/29238343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01638
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