Inhibition of the sarco/endoplasmic reticulum (ER) Ca(2+)-ATPase by thapsigargin analogs induces cell death via ER Ca(2+) depletion and the unfolded protein response

Calcium (Ca(2+)) is a fundamental regulator of cell signaling and function. Thapsigargin (Tg) blocks the sarco/endoplasmic reticulum (ER) Ca(2+)-ATPase (SERCA), disrupts Ca(2+) homeostasis, and causes cell death. However, the exact mechanisms whereby SERCA inhibition induces cell death are incomplet...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Sehgal, Pankaj, Szalai, Paula, Olesen, Claus, Praetorius, Helle A., Nissen, Poul, Christensen, Søren Brøgger, Engedal, Nikolai, Møller, Jesper V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712609/
https://ncbi.nlm.nih.gov/pubmed/28972171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.796920
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