Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair

Granular corneal dystrophy (GCD) is an autosomal dominant hereditary disease in which multiple discrete and irregularly shaped granular opacities are deposited in the corneal stroma. GCD is caused by a point mutation in the transforming growth factor-β-induced (TGFBI) gene, located on chromosome 5q3...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Taketani, Yukako, Kitamoto, Kohdai, Sakisaka, Toshihiro, Kimakura, Mikiko, Toyono, Tetsuya, Yamagami, Satoru, Amano, Shiro, Kuroda, Masahiko, Moore, Tara, Usui, Tomohiko, Ouchi, Yasuo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711889/
https://ncbi.nlm.nih.gov/pubmed/29196743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16308-2
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