Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair

Granular corneal dystrophy (GCD) is an autosomal dominant hereditary disease in which multiple discrete and irregularly shaped granular opacities are deposited in the corneal stroma. GCD is caused by a point mutation in the transforming growth factor-β-induced (TGFBI) gene, located on chromosome 5q3...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Taketani, Yukako, Kitamoto, Kohdai, Sakisaka, Toshihiro, Kimakura, Mikiko, Toyono, Tetsuya, Yamagami, Satoru, Amano, Shiro, Kuroda, Masahiko, Moore, Tara, Usui, Tomohiko, Ouchi, Yasuo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711889/
https://ncbi.nlm.nih.gov/pubmed/29196743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16308-2
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