Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome

Pathogenesis of chronic lymphocytic leukaemia (CLL) is contingent upon antigen receptor (BCR) expressed by malignant cells of this disease. Studies on somatic hypermutation of the antigen binding region, receptor expression levels and signal capacity have all linked BCR on CLL cells to disease progn...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Till, Kathleen J., Allen, John C., Talab, Fatima, Lin, Ke, Allsup, David, Cawkwell, Lynn, Bentley, Alison, Ringshausen, Ingo, Duckworth, Andrew D., Pettitt, Andrew R., Kalakonda, Nagesh, Slupsky, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711840/
https://ncbi.nlm.nih.gov/pubmed/29196709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17021-w
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