Sevoflurane causes greater QTc interval prolongation in chronically hyperglycemic patients than in normoglycemic patients

QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval p...

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Vydáno v:PLoS One
Hlavní autoři: Kimura, Seishi, Nakao, Shinichi, Kitaura, Atsuhiro, Iwamoto, Tatushige, Houri, Kei, Matsushima, Mayuka, Hamasaki, Shinichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711029/
https://ncbi.nlm.nih.gov/pubmed/29194447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188555
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