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X-ray Absorption Spectroscopy Reveals an Organometallic Ni–C Bond in the CO-Treated Form of Acetyl-CoA Synthase

Acetyl-CoA synthase (ACS) is a key enzyme in the Wood–Ljungdahl pathway of anaerobic CO(2) fixation, which has long been proposed to operate by a novel mechanism involving a series of protein-bound organometallic (Ni–CO, methyl–Ni, and acetyl–Ni) intermediates. Here we report the first direct struct...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Can, Mehmet, Giles, Logan J., Ragsdale, Stephen W., Sarangi, Ritimukta
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710745/
https://ncbi.nlm.nih.gov/pubmed/28186407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00983
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