A carregar...

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

Senescence is a terminal differentiation program that halts the growth of damaged cells and must be circumvented for cancer to arise. Here we describe a panel of genetic screens to identify genes required for replicative senescence. We uncover a role in senescence for the potent tumor suppressor and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Mazzucco, Anna E., Smogorzewska, Agata, Kang, Chanhee, Luo, Ji, Schlabach, Michael R., Xu, Qikai, Patel, Rupesh, Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710139/
https://ncbi.nlm.nih.gov/pubmed/29089421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.304857.117
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!