Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

BACKGROUND: Alzheimer’s disease (AD) is the most common type of dementia, affecting one in eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown etiology, and only 5% of all patients with AD present the familial monogenic form of the disease. In the present study, ou...

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Bibliografiske detaljer
Udgivet i:Alzheimers Res Ther
Main Authors: Ochalek, Anna, Mihalik, Balázs, Avci, Hasan X., Chandrasekaran, Abinaya, Téglási, Annamária, Bock, István, Giudice, Maria Lo, Táncos, Zsuzsanna, Molnár, Kinga, László, Lajos, Nielsen, Jørgen E., Holst, Bjørn, Freude, Kristine, Hyttel, Poul, Kobolák, Julianna, Dinnyés, András
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709977/
https://ncbi.nlm.nih.gov/pubmed/29191219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-017-0317-z
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