APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing

Apurinic/apyrimidinic endonuclease 1/redox factor‐1 (APE1/Ref‐1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer‐related pathways. Because APE1 is essential for cell viability, generation of APE1‐knockout cell lines and determining a comprehe...

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Publicado en:Mol Oncol
Autores principales: Shah, Fenil, Goossens, Emery, Atallah, Nadia M., Grimard, Michelle, Kelley, Mark R., Fishel, Melissa L.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709621/
https://ncbi.nlm.nih.gov/pubmed/28922540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12138
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