DR5‐Cbl‐b/c‐Cbl‐TRAF2 complex inhibits TRAIL‐induced apoptosis by promoting TRAF2‐mediated polyubiquitination of caspase‐8 in gastric cancer cells

Ubiquitination of caspase‐8 regulates TNF‐related apoptosis‐inducing ligand (TRAIL) sensitivity in cancer cells, and the preligand assembly complex plays a role in caspase‐8 polyubiquitination. However, whether such a complex exists in gastric cancer cells and its role in TRAIL‐triggered apoptosis i...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Xu, Ling, Zhang, Ye, Qu, Xiujuan, Che, Xiaofang, Guo, Tianshu, Li, Ce, Ma, Rui, Fan, Yibo, Ma, Yanju, Hou, Kezuo, Li, Danni, Hu, Xuejun, Liu, Bofang, Yu, Ruoxi, Yan, Hongfei, Gong, Jing, Liu, Yunpeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709619/
https://ncbi.nlm.nih.gov/pubmed/28972304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12140
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