DR5‐Cbl‐b/c‐Cbl‐TRAF2 complex inhibits TRAIL‐induced apoptosis by promoting TRAF2‐mediated polyubiquitination of caspase‐8 in gastric cancer cells

Ubiquitination of caspase‐8 regulates TNF‐related apoptosis‐inducing ligand (TRAIL) sensitivity in cancer cells, and the preligand assembly complex plays a role in caspase‐8 polyubiquitination. However, whether such a complex exists in gastric cancer cells and its role in TRAIL‐triggered apoptosis i...

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Bibliografski detalji
Izdano u:Mol Oncol
Glavni autori: Xu, Ling, Zhang, Ye, Qu, Xiujuan, Che, Xiaofang, Guo, Tianshu, Li, Ce, Ma, Rui, Fan, Yibo, Ma, Yanju, Hou, Kezuo, Li, Danni, Hu, Xuejun, Liu, Bofang, Yu, Ruoxi, Yan, Hongfei, Gong, Jing, Liu, Yunpeng
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709619/
https://ncbi.nlm.nih.gov/pubmed/28972304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12140
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