DR5‐Cbl‐b/c‐Cbl‐TRAF2 complex inhibits TRAIL‐induced apoptosis by promoting TRAF2‐mediated polyubiquitination of caspase‐8 in gastric cancer cells

Ubiquitination of caspase‐8 regulates TNF‐related apoptosis‐inducing ligand (TRAIL) sensitivity in cancer cells, and the preligand assembly complex plays a role in caspase‐8 polyubiquitination. However, whether such a complex exists in gastric cancer cells and its role in TRAIL‐triggered apoptosis i...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Xu, Ling, Zhang, Ye, Qu, Xiujuan, Che, Xiaofang, Guo, Tianshu, Li, Ce, Ma, Rui, Fan, Yibo, Ma, Yanju, Hou, Kezuo, Li, Danni, Hu, Xuejun, Liu, Bofang, Yu, Ruoxi, Yan, Hongfei, Gong, Jing, Liu, Yunpeng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709619/
https://ncbi.nlm.nih.gov/pubmed/28972304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12140
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