In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice

Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in wild birds and limited immunity in the human population. In the event of a pandemic, antiviral agents are the mainstay for treatment...

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Udgivet i:J Virol
Main Authors: Sutton, Troy C., Lamirande, Elaine W., Bock, Kevin W., Moore, Ian N., Koudstaal, Wouter, Rehman, Muniza, Weverling, Gerrit Jan, Goudsmit, Jaap, Subbarao, Kanta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709608/
https://ncbi.nlm.nih.gov/pubmed/29046448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01603-17
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