In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice

Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in wild birds and limited immunity in the human population. In the event of a pandemic, antiviral agents are the mainstay for treatment...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Sutton, Troy C., Lamirande, Elaine W., Bock, Kevin W., Moore, Ian N., Koudstaal, Wouter, Rehman, Muniza, Weverling, Gerrit Jan, Goudsmit, Jaap, Subbarao, Kanta
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709608/
https://ncbi.nlm.nih.gov/pubmed/29046448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01603-17
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