Pre‐clinical evaluation of N‐acetylcysteine reveals side effects in the mdx mouse model of Duchenne muscular dystrophy

KEY POINTS: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease associated with increased inflammation and oxidative stress. The antioxidant N‐acetylcysteine (NAC) has been proposed as a therapeutic intervention for DMD boys, but potential adverse effects of NAC have not been widely...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Physiol
Auteurs principaux: Pinniger, Gavin J., Terrill, Jessica R., Assan, Evanna B., Grounds, Miranda D., Arthur, Peter G.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Muscle
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709333/
https://ncbi.nlm.nih.gov/pubmed/28887840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274229
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