Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz

BACKGROUND: Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), has been widely used in the therapy of human immunodeficiency virus (HIV) infection. Some of its toxic effects on hepatic cells have been reported to display features of mitochondrial dysfunction through bioenerge...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tan, Zhimi, Jia, Xiaofang, Ma, Fang, Feng, Yanling, Lu, Hongzhou, Jin, Jun-O, Wu, Dage, Yin, Lin, Liu, Li, Zhang, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708658/
https://ncbi.nlm.nih.gov/pubmed/29190729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188366
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