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An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors

An enantioselective synthesis of (3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-ol, a high-affinity nonpeptide ligand for a variety of potent HIV-1 protease inhibitors is described. The key steps involved a highly enantioselective enzymatic desymmetrization of meso-diacetate, an efficient transacetali...

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Publicat a:Tetrahedron Lett
Autors principals: Ghosh, Arun K., Sarkar, Anindya
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708567/
https://ncbi.nlm.nih.gov/pubmed/29200514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.07.010
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