Early transcriptional divergence marks virus-specific primary human CD8(+) T cells in chronic versus acute infection

Distinct molecular pathways govern the differentiation of CD8(+) effector T cells into memory or exhausted T cells during acute and chronic viral infection but these are not well-studied in humans. Here, we employed an integrative systems immunology approach to identify transcriptional commonalities...

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發表在:Immunity
Main Authors: Wolski, David, Foote, Peter, Chen, Diana, Lewis-Ximenez, Lia L, Fauvelle, Catherine, Aneja, Jasneet, Walker, Andreas, Tonnerre, Pierre, Torres-Cornejo, Almudena, Kvistad, Daniel, Imam, Sabrina, Waring, Michael T, Tully, Damien C, Allen, Todd M, Chung, Raymond T, Timm, Jörg, Haining, W Nicholas, Kim, Arthur Y, Baumert, Thomas F, Lauer, Georg M
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708133/
https://ncbi.nlm.nih.gov/pubmed/29045899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.09.006
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