O-GlcNAcylation is required for B cell homeostasis and antibody responses

O-linked N-acetylglucosamine (O-GlcNAc) transferase (Ogt) catalyzes O-GlcNAc modification. O-GlcNAcylation is increased after cross-linking of the B-cell receptor (BCR), but the physiological function of this reaction is unknown. Here we show that lack of Ogt in B-cell development not only causes se...

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Publicado no:Nat Commun
Main Authors: Wu, Jung-Lin, Chiang, Ming-Feng, Hsu, Pan-Hung, Tsai, Dong-Yen, Hung, Kuo-Hsuan, Wang, Ying-Hsiu, Angata, Takashi, Lin, Kuo-I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707376/
https://ncbi.nlm.nih.gov/pubmed/29187734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01677-z
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