Hepatocyte Growth Factor Activator Inhibitor Type 1 Maintains the Assembly of Keratin into Desmosomes in Keratinocytes by Regulating Protease-Activated Receptor 2–Dependent p38 Signaling

Hepatocyte growth factor activator inhibitor type 1 (HAI-1; official symbol SPINT1) is a membrane-associated serine proteinase inhibitor abundantly expressed in epithelial tissues. Genetically engineered mouse models demonstrated that HAI-1 is critical for epidermal function, possibly through direct...

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Publié dans:Am J Pathol
Auteurs principaux: Kawaguchi, Makiko, Kanemaru, Ai, Sawaguchi, Akira, Yamamoto, Koji, Baba, Takashi, Lin, Chen-Yong, Johnson, Michael D., Fukushima, Tsuyoshi, Kataoka, Hiroaki
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707200/
https://ncbi.nlm.nih.gov/pubmed/25842366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.02.009
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