Detection of High-Frequency and Novel DNMT3A Mutations in Acute Myeloid Leukemia by High-Resolution Melting Curve Analysis

DNA methyltransferase 3A (DNMT3A) is mutated in a subset of de novo acute myeloid leukemia patients and is associated with poor overall and event-free survival. Because routine Sanger sequencing of the 23 DNMT3A exons is impractical in clinical laboratories, we developed a high-throughput method usi...

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Dades bibliogràfiques
Publicat a:J Mol Diagn
Autors principals: Singh, Rajesh R., Bains, Ashish, Patel, Keyur P., Rahimi, Hamed, Barkoh, Bedia A., Paladugu, Abhaya, Bisrat, Tigist, Ravandi-Kashani, Farhad, Cortes, Jorge E., Kantarjian, Hagop M., Medeiros, L. Jeffrey, Luthra, Rajyalakshmi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707199/
https://ncbi.nlm.nih.gov/pubmed/22642896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2012.02.009
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