p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an “obligatory” haploinsufficient tumor suppressor. Whereas monoallelic loss o...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Short, Sarah P., Kondo, Jumpei, Smalley-Freed, Whitney G., Takeda, Haruna, Dohn, Michael R., Powell, Anne E., Carnahan, Robert H., Washington, Mary K., Tripathi, Manish, Payne, D. Michael, Jenkins, Nancy A., Copeland, Neal G., Coffey, Robert J., Reynolds, Albert B.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707165/
https://ncbi.nlm.nih.gov/pubmed/29130932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77217
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