p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an “obligatory” haploinsufficient tumor suppressor. Whereas monoallelic loss o...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Short, Sarah P., Kondo, Jumpei, Smalley-Freed, Whitney G., Takeda, Haruna, Dohn, Michael R., Powell, Anne E., Carnahan, Robert H., Washington, Mary K., Tripathi, Manish, Payne, D. Michael, Jenkins, Nancy A., Copeland, Neal G., Coffey, Robert J., Reynolds, Albert B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707165/
https://ncbi.nlm.nih.gov/pubmed/29130932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77217
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