Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C

Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers....

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Vydáno v:J Clin Invest
Hlavní autoři: Kedves, Alexia T., Gleim, Scott, Liang, Xiaoyou, Bonal, Dennis M., Sigoillot, Frederic, Harbinski, Fred, Sanghavi, Sneha, Benander, Christina, George, Elizabeth, Gokhale, Prafulla C., Nguyen, Quang-De, Kirschmeier, Paul T., Distel, Robert J., Jenkins, Jeremy, Goldberg, Michael S., Forrester, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707153/
https://ncbi.nlm.nih.gov/pubmed/29130934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92914
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