Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload

Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constric...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Toischer, Karl, Zhu, Wuqiang, Hünlich, Mark, Mohamed, Belal A., Khadjeh, Sara, Reuter, Sean P., Schäfer, Katrin, Ramanujam, Deepak, Engelhardt, Stefan, Field, Loren J., Hasenfuss, Gerd
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707145/
https://ncbi.nlm.nih.gov/pubmed/29083322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81870
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