Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload

Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constric...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Toischer, Karl, Zhu, Wuqiang, Hünlich, Mark, Mohamed, Belal A., Khadjeh, Sara, Reuter, Sean P., Schäfer, Katrin, Ramanujam, Deepak, Engelhardt, Stefan, Field, Loren J., Hasenfuss, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707145/
https://ncbi.nlm.nih.gov/pubmed/29083322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81870
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