Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts

Calcium/calmodulin-dependent protein kinase type II delta (CaMKIIδ), the predominant CaMKII isoform expressed in the heart, has been implicated in the progression of myocardial infarction- and pressure overload-induced pathological remodeling. However, the role of CaMKIIδ in volume overload (VO) has...

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Published in:Sci Rep
Main Authors: Mohamed, Belal A., Elkenani, Manar, Jakubiczka-Smorag, Joanna, Buchholz, Eric, Koszewa, Sabrina, Lbik, Dawid, Schnelle, Moritz, Hasenfuss, Gerd, Toischer, Karl
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614357/
https://ncbi.nlm.nih.gov/pubmed/31285482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46332-3
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