Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

Asymmetric division generates cellular diversity by producing daughter cells with different fates. In animals, the mitotic spindle aligns with Par complex polarized fate determinants, ensuring that fate determinant cortical domains are bisected by the cleavage furrow. Here, we investigate the mechan...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Golub, Ognjen, Wee, Brett, Newman, Rhonda A, Paterson, Nicole M, Prehoda, Kenneth E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2017
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706957/
https://ncbi.nlm.nih.gov/pubmed/29185419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32137
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