Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division

Asymmetric division generates cellular diversity by producing daughter cells with different fates. In animals, the mitotic spindle aligns with Par complex polarized fate determinants, ensuring that fate determinant cortical domains are bisected by the cleavage furrow. Here, we investigate the mechan...

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Veröffentlicht in:eLife
Hauptverfasser: Golub, Ognjen, Wee, Brett, Newman, Rhonda A, Paterson, Nicole M, Prehoda, Kenneth E
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706957/
https://ncbi.nlm.nih.gov/pubmed/29185419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32137
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