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Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells

BIRC5 encodes the protein survivin, a member of the inhibitor of apoptosis family. Survivin is highly expressed in a variety of cancers but has very low expression in the corresponding normal tissues, and its expression is often associated with tumor metastasis and chemoresistance. We report that su...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Oncotarget
Main Authors: Zhao, Guannan, Wang, Qinghui, Gu, Qingqing, Qiang, Wenan, Wei, Jian-Jun, Dong, Peixin, Watari, Hidemichi, Li, Wei, Yue, Junming
פורמט: Artigo
שפה:Inglês
יצא לאור: Impact Journals LLC 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706903/
https://ncbi.nlm.nih.gov/pubmed/29212257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21863
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