Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

BACKGROUND: Controversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen can predict breast cancer outcome in patients using adjuvant tamoxifen. Direct measurement of concentrations of active tamoxifen metabolites in serum may be a more biolo...

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Bibliografiske detaljer
Udgivet i:Breast Cancer Res
Main Authors: Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela N., Kvaløy, Jan T., Lash, Timothy L., Alnæs, Grethe I. G., van Schaik, Ron H., Janssen, Emiel A. M., Hustad, Steinar, Lien, Ernst A., Mellgren, Gunnar, Søiland, Håvard
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706168/
https://ncbi.nlm.nih.gov/pubmed/29183390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-017-0916-4
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