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Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease

Mitochondrial dysfunction is involved in a wide array of devastating diseases, but the heterogeneity and complexity of the symptoms of these diseases challenges theoretical understanding of their causation. With the explosion of omics data, we have the unprecedented opportunity to gain deep understa...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Aryaman, Juvid, Johnston, Iain G., Jones, Nick S.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705840/
https://ncbi.nlm.nih.gov/pubmed/29079678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170651
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