GSK-3β Inhibition Suppresses Instability-induced Osteolysis by a Dual Action on Osteoblast and Osteoclast Differentiation

Currently, there are no medications available to treat aseptic loosening of orthopedic implants. Using osteoprotegerin fusion protein (OPG-Fc), we previously blocked instability-induced osteoclast differentiation and peri-prosthetic osteolysis. Wnt/β-catenin signaling, which regulates OPG secretion...

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Xehetasun bibliografikoak
Argitaratua izan da:J Cell Physiol
Egile Nagusiak: Amirhosseini, Mehdi, Madsen, Rune V., Escott, K. Jane, Bostrom, Mathias P., Ross, F. Patrick, Fahlgren, Anna
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705568/
https://ncbi.nlm.nih.gov/pubmed/28731198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26111
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