Activity-Dependent BDNF Release is Required for the Rapid Antidepressant Actions of Scopolamine

BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology and treatment of depression. Recent clinical studies demonstrate that scopolamine, a non-selective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in depressed patients. R...

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Publicat a:Biol Psychiatry
Autors principals: Ghosal, Sriparna, Bang, Eunyoung, Yue, Wenzhu, Hare, Brendan D., Lepack, Ashley E., Girgenti, Matthew J., Duman, Ronald S.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705490/
https://ncbi.nlm.nih.gov/pubmed/28751069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.06.017
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