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A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy

BACKGROUND: Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection and cardiomyopathy. While significant advances in the understanding of TGF-β signaling have led to promising therapeutic tar...

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Publicat a:Ann Thorac Surg
Autors principals: Cavanaugh, Nicholas B., Qian, Lan, Kutschke, William J., Born, Ella J., Turek, Joseph W.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705055/
https://ncbi.nlm.nih.gov/pubmed/28347539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2016.10.077
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