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Mapping DNA Methylation with High Throughput Nanopore Sequencing
Chemical modifications to DNA regulate its biological function. We present a framework for mapping methylation to cytosine and adenosine with the Oxford Nanopore Technologies MinION using its ionic current signal. We map three cytosine variants and two adenine variants. The results show that our mod...
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| Publicado en: | Nat Methods |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5704956/ https://ncbi.nlm.nih.gov/pubmed/28218897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4189 |
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