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Preferential association with ClC-3 permits sorting of ClC-4 into endosomal compartments

ClC-4 is an intracellular Cl(−)/H(+) exchanger that is highly expressed in the brain and whose dysfunction has been linked to intellectual disability and epilepsy. Here we studied the subcellular localization of human ClC-4 in heterologous expression systems. ClC-4 is retained in the endoplasmic ret...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Guzman, Raul E., Bungert-Plümke, Stefanie, Franzen, Arne, Fahlke, Christoph
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704486/
https://ncbi.nlm.nih.gov/pubmed/28972156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.801951
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