Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins

Plasma membrane (PM) localization of Ras proteins is crucial for transmitting signals upon mitogen stimulation. Post-translational lipid modification of Ras proteins plays an important role in their recruitment to the PM. Electrostatic interactions between negatively charged PM phospholipids and bas...

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Publicado en:J Biol Chem
Autores principales: Gulyás, Gergő, Radvánszki, Glória, Matuska, Rita, Balla, András, Hunyady, László, Balla, Tamas, Várnai, Péter
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704471/
https://ncbi.nlm.nih.gov/pubmed/28939768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806679
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