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Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor

Receptor endocytosis plays an important role in regulating the responsiveness of cells to specific ligands. Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] has been shown to be crucial for endocytosis of some cell surface receptors, such as EGF and transferrin receptors, but its role in G-pr...

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Detalhes bibliográficos
Main Authors: Tóth, Dániel J., Tóth, József T., Gulyás, Gergö, Balla, András, Balla, Tamas, Hunyady, László, Várnai, Péter
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367940/
https://ncbi.nlm.nih.gov/pubmed/22357943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.097279
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