Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in vitro and in vivo, and led to resistance to autoi...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Wang, Xiaohu, Ni, Lu, Chang, Dehui, Lu, Huiping, Jiang, Yu, Kim, Byung-Seok, Wang, Aibo, Liu, Xindong, Zhong, Bo, Yang, Xuexian, Dong, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704088/
https://ncbi.nlm.nih.gov/pubmed/29050947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.10.010
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