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Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer’s disease drug candidates

SLM and SLOH, two analogues of carbazole-based cyanine compounds, have been shown to inhibit β-amyloid peptide aggregation in vitro and in Alzheimer’s disease model mice, which could be potentially developed into drugs for disease treatment. To pave the way for further pharmacokinetics-pharmacodynam...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Zhou, Wei, Hu, Xiaohui, Tam, Kin Yip
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703966/
https://ncbi.nlm.nih.gov/pubmed/29180684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16635-4
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