DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA

Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat (VR) that results in adenine-to-random nucleotid...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Naorem, Santa S., Han, Jin, Wang, Shufang, Lee, William R., Heng, Xiao, Miller, Jeff F., Guo, Huatao
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703328/
https://ncbi.nlm.nih.gov/pubmed/29109248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715952114
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