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Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types
Autoantibodies to citrullinated proteins (ACPAs) are present in two-thirds of patients with rheumatoid arthritis (RA). ACPAs are produced in the absence of identified T cell responses for each citrullinated protein. Peptidyl arginine deiminase 4 (PAD4), which binds proteins and citrullinates them, i...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5703315/ https://ncbi.nlm.nih.gov/pubmed/29109281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713112114 |
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