Preparation, Evaluation and Bioavailability Studies of Eudragit Coated PLGA Nanoparticles for Sustained Release of Eluxadoline for the Treatment of Irritable Bowel Syndrome

Eluxadoline is a newly approved orally administered drug used for the treatment of Irritable Bowel Syndrome with Diarrhea. It is reported as a poorly water-soluble drug due to which its dissolution rate and oral bioavailability are very poor. In this work, various plain PLGA nanoparticles (NPs) (F1–...

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Publicat a:Front Pharmacol
Autors principals: Anwer, Md. K., Al-Shdefat, Ramadan, Ezzeldin, Essam, Alshahrani, Saad M., Alshetaili, Abdullah S., Iqbal, Muzaffar
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702012/
https://ncbi.nlm.nih.gov/pubmed/29209215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00844
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