Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats

BACKGROUND: Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it is classified as a class IV drug according to BCS classification. Dose titration is recommended during APM treat...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Anwer, Md Khalid, Mohammad, Muqtader, Ezzeldin, Essam, Fatima, Farhat, Alalaiwe, Ahmed, Iqbal, Muzaffar
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402442/
https://ncbi.nlm.nih.gov/pubmed/30880967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S195048
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