Inhibition of beta-catenin signaling in the skin rescues cutaneous adipogenesis in systemic sclerosis: a randomized, double blind, placebo-controlled trial of C-82

Several studies have suggested that Wnts might contribute to skin fibrosis in systemic sclerosis (SSc) by affecting the differentiation of pluripotent dermal cells. We tested C-82, a therapeutic that inhibits canonical Wnt signaling by blocking the interaction of cAMP Response Element-Binding Protei...

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Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Lafyatis, Robert, Mantero, Julio C., Gordon, Jessica, Kishore, Nina, Carns, Mary, Dittrich, Howard, Spiera, Robert, Simms, Robert W., Varga, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701831/
https://ncbi.nlm.nih.gov/pubmed/28807667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.06.032
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