Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers

Spinal muscular atrophy (SMA) is a neurodegenerative disorder that results from mutations in the SMN1 gene, leading to survival motor neuron (SMN) protein deficiency. One therapeutic strategy for SMA is to identify compounds that enhance the expression of the SMN2 gene, which normally only is a mino...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Choi, Sungwoon, Calder, Alyssa N., Miller, Eliza H., Anderson, Kierstyn P., Fiejtek, Dawid K., Rietz, Anne, Li, Hongxia, Cherry, Jonathan J., Quist, Kevin M., Xing, Xuechao, Glicksman, Marcie A., Cuny, Gregory D., Lorson, Christian L., Androphy, Elliot A., Hodgetts, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701662/
https://ncbi.nlm.nih.gov/pubmed/29103974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.066
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