HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HIFs) are the most prevalent molecular features of clear cell tumors. The significance of lipid de...

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Udgivet i:Nat Commun
Main Authors: Du, Weinan, Zhang, Luchang, Brett-Morris, Adina, Aguila, Brittany, Kerner, Janos, Hoppel, Charles L., Puchowicz, Michelle, Serra, Dolors, Herrero, Laura, Rini, Brian I., Campbell, Steven, Welford, Scott M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701259/
https://ncbi.nlm.nih.gov/pubmed/29176561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01965-8
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