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HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HIFs) are the most prevalent molecular features of clear cell tumors. The significance of lipid de...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5701259/ https://ncbi.nlm.nih.gov/pubmed/29176561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01965-8 |
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