Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon activity. We demonstrate that miR-21-5p is released in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Simeoli, Raffaele, Montague, Karli, Jones, Hefin R., Castaldi, Laura, Chambers, David, Kelleher, Jayne H., Vacca, Valentina, Pitcher, Thomas, Grist, John, Al-Ahdal, Hadil, Wong, Liang-Fong, Perretti, Mauro, Lai, Johnathan, Mouritzen, Peter, Heppenstall, Paul, Malcangio, Marzia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701122/
https://ncbi.nlm.nih.gov/pubmed/29176651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01841-5
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