Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon activity. We demonstrate that miR-21-5p is released in...

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發表在:Nat Commun
Main Authors: Simeoli, Raffaele, Montague, Karli, Jones, Hefin R., Castaldi, Laura, Chambers, David, Kelleher, Jayne H., Vacca, Valentina, Pitcher, Thomas, Grist, John, Al-Ahdal, Hadil, Wong, Liang-Fong, Perretti, Mauro, Lai, Johnathan, Mouritzen, Peter, Heppenstall, Paul, Malcangio, Marzia
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701122/
https://ncbi.nlm.nih.gov/pubmed/29176651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01841-5
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